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- Keywords DNA vaccines;NDV;progress; DNA疫苗;新城疫;进展;
- Keywords DNA vaccine;Hepatitis B;Hepatitis B virus core antigen;Immunogenicity; 核酸疫苗;肝炎;乙型;核心抗原;肝炎病毒;免疫原性;
- Keywords DNA vaccine;Hepatitis B virus;Hepatitis B;Interferon;Thymosin; 疫苗;DNA;肝炎病毒;乙型;肝炎;干扰素;胸腺素;
- Keywords DNA vaccine;Xenogeneic homologous gene;CD154;Hepatic fibrosis;Active immunotherapy; DNA疫苗;异种同源基因;肝纤维化;自身反应性抗体;
- Keywords DNA vaccine;colorectal cancer;CEA（carcinoembryonic antigen）;coexpression plasmid;antitumor immune response; DNA疫苗;结直肠癌;癌胚抗原;双表达质粒;抗肿瘤免疫;
- Keywords DNA vaccine;infectious bursal disease virus;polyprotein（VP2/VP4/VP3）;immunogenicity;neutralization antibody;ISCOM; 传染性法氏囊病病毒;多聚蛋白;DNA疫苗;免疫原性;中和抗体;免疫刺激复合物（ISCOM）;
- This review summarized the current situation of study on routes of DNA vaccines immunization. 该文对DNA疫苗免疫各种途径的研究现状作一综述。
- Results: Immune effects of DNA vaccines were enhanced following electric pulses and bupivacaine delivery. 检测免疫小鼠的抗体和细胞水平，并分析抗体亚类。
- A variety of approaches have been taken to augment and modulate the immunogenicity and efficacy of plasmid DNA vaccines. 核酸疫苗虽然在小动物实验中取得成功,但对大动物、灵长类动物和人类的免疫原性却很低。
- Objective To construct a multivalent DNA vaccine. 目的构建日本血吸虫多价DNA疫苗。
- Keywords biolistics;DNA vaccines;neoplasm antigens; 生物弹道技术;DNA疫苗;肿瘤抗原;
- The combined PCX/S antigen gene could induce specific immune response and it might be able to serve as a bivalent DNA vaccines candidate specific for HCV and HBV. 复合型PCX/S抗原基因可诱发特异性免疫应答,为HCV/HBV双价疫苗的研究提供一定实验基础。
- While small animal studies have been extremely promising, the immunogenicity of DNA vaccines in larger animals, non-human primates and humans has been disappointing. 从抗原基因的选择、质粒载体的优化、接种方法的优化和免疫佐剂的选用等方面综述核酸疫苗的优化方案。
- Genetic vaccines and DNA vaccines are being exploited.The targets are Toxoplasma gondii, pneumocystis carinii, Cryptosporidium parvum, and Angiostrongylus cantonensis. 主要的研究对象为弓形虫、卡氏肺孢子虫、隐孢子虫、广州管圆线虫等。
- Hepatitis B vaccines progressed from blood vaccines to recombinant vaccines,then to peptide vaccines and DNA vaccines,to their functions extended from prophylactic to therapeutic. 从第一代血源性疫苗到重组乙肝疫苗,再到合成肽疫苗和DNA疫苗,乙肝疫苗的研制技术不断进步,其应用范围也已从预防扩展到治疗。
- Hepatitis B vaccines progressed from blood vaccines to recombinant vaccines, then to peptide vaccines and DNA vaccines, to their functions extended from prophylactic to therapeutic. 从第一代血源性疫苗到重组乙肝疫苗，再到合成肽疫苗和DNA疫苗，乙肝疫苗的研制技术不断进步，其应用范围也已从预防扩展到治疗。
- Eukaryotic expression recombinant plasmids pcDNA3-ORF2,pcDNA3-V1,pcDNA3-V2,pcDNA3-V3 and pcDNA3-V1-V2 were constructed by using pcDNA3,PCV2 ORF2,and the variant regions of PCV2 ORF2 in order to develop DNA vaccines against porcine circovirus type 2(PCV2). 为研制猪2型圆环病毒(PCV2)新型核酸疫苗,以pcDNA3为载体,与PCV2的ORF2及其高变区V1、V2、V3、V1-V2连接,分别成功构建了真核表达质粒pcDNA3-ORF2、pcDNA3-V1、pcDNA3-V2、pcDNA3-V3和pcDNA3-V1-V2。
- Objective: To construct an eukaryotic co-expression recombinant containing mouse interleukin 21(IL-21) and tuberculosis antigen 85A(Ag85A), it provides the new strategy for further development of new type anti-tuberculosis DNA vaccines. 目的:利用真核表达质粒pRSC,构建结核杆菌抗原85A(Ag85A)与小鼠白细胞介素21(mIL21)共表达重组体pRSC-mIL21-Ag85A,为研究新型结核杆菌DNA疫苗提供新的策略。
- Conclusion Cellular immunity in mice could be enhanced induced by DNA vaccines based on HPV16 E6/E7. It could be much stronger induced by DNA recombinants of HSP70 of mycobacterium tuberculosis and HPV16 E6/E7. However, humoral immunity remained. 与结核杆菌HSP70重组后,IL-10及抗体水平没有明显变化。 结论以HPV16 E6/E7为基础的DNA免疫能增强小鼠的细胞免疫反应。
- METHODS:The DNA vaccines, pVR1012-L, pVR1012-M and pVR1012-S, were constructed by inserting HBV envelope gene fragments into plasmid pVR1012. The expression of them in COS7 cell line was examined by Enzyme-linked immunosorbent assay (ELISA) method. 方法:构建质粒pVR1012-L;pVR1012-M;pVR1012-S.;转染COS7细胞系进行表达
